Cost-Effective Interventions

Interventions are actions taken by or for individuals to reduce the risk, duration, or severity of adverse health conditions. Interventions may be population-based or personal.

DCP2 and GBD present what we know about which health interventions work for a comprehensive range of diseases, injuries, and disabilities in many different contexts. A large share of the disease burden in low- and middle-income countries is attributable to diseases and conditions for which cost-effective interventions are already known and feasible. Selecting the right intervention for a given disease and context matters a great deal. The tools on this page are designed to aid the task.

DCP2 and GBD demonstrate how decision makers could use cost-effectiveness information in combination with information on disease prevalence and avertable illness to determine which interventions should be extended and which ones should be questioned. If developing countries scale up interventions and extend health care services that are cost-effective, the impact on the disease burden could be substantial.

Select Criteria

Disease / Condition Setting Type Objective Target population

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Condition Intervention Intervention type Intervention description Intervention setting Objective Target population Cost effectiveness (US$/DALY) Cost effectiveness estimate (US$) Cost effectiveness range (US$/DALY) Number of DALYs averted (hundreds) Number of deaths averted (hundreds) Quality of cost-effectiveness analysis evidence
HIV/AIDS Antiretroviral therapy Personal Combination therapy with multiple antiretroviral drugs associated with prolonged survival in treated patients Clinic primary prevention All ages, Adults, Infants or children, Women of childbearing age, Pregnant women, Adolescents and adults, Mothers and infants 922 (SubSaharan Africa) - 350-1,494 (SubSaharan Africa) -- -- 3 (Sub-Saharan Africa)
HIV/AIDS Blood and needle safety Population Screening of all blood for transfusions; sterilization for all injections; harm reduction for injecting drug users, including needle exchange and drug substitution programs Community, Clinic, Referral hospital, Local or district hospital population-oriented medical intervention All ages, Adults, Infants or children, Women of childbearing age, Pregnant women, Adolescents and adults, Mothers and infants 84 (Sub-Saharan Africa) - 7-161 (SubSaharan Africa) -- -- 2 (SubSaharan Africa)
HIV/AIDS Condom promotion and distribution Population Targeted distribution and placement of condoms in locations such as bars or brothels; distribution linked to voluntary counseling and testing and sexually transmitted infection care to ensure universal access; information, education, and communication, in Community, Clinic personal behavior change Adults, Women of childbearing age, Pregnant women, Adolescents and adults 82 (Sub-Saharan Africa) - 52-112 (SubSaharan Africa) -- -- 1 (SubSaharan Africa)
HIV/AIDS Home care Personal Home visits providing basic care to sick AIDS patients or comprehensive schemes that provide palliative care, nutrition, psychosocial support and counseling, and links to primary and secondary health care Home secondary prevention, palliation All ages, Adults, Infants or children, Women of childbearing age, Pregnant women, Adolescents and adults, Mothers and infants 673 (SubSaharan Africa) - -- -- -- 2 (Sub-Saharan Africa)
HIV/AIDS Mother-to-child transmission prevention Personal All pregnant women offered screening to prevent mother-tochild transmission; administration of a short-course of AZT, lamivudine, or nevirapine to mothers prepartum and intrapartum and to newborns postpartum to reduce the risk of motherto-child transmissi Clinic primary prevention Infants or children, Women of childbearing age, Pregnant women, Mothers and infants 192 - 7-377 -- -- 2
HIV/AIDS Peer and education programs for high-risk groups Population Targeting community members (for example, students or commercial sex workers) to disseminate information and teach specific skills Community personal behavior change Adults, Women of childbearing age, Pregnant women, Adolescents and adults 37 - 6-68 -- -- 2
HIV/AIDS Sexually transmitted infection diagnosis and treatment Personal Sexually transmitted infection screening and treatment promotion to prevent future infection and to identify and treat highrisk populations Clinic primary prevention, cure Adults, Women of childbearing age, Pregnant women, Adolescents and adults 57 (SubSaharan Africa) - 9-105 (SubSaharan Africa) -- -- 2 (Sub-Saharan Africa)
HIV/AIDS Treatment of Kaposi's sarcoma Personal Treatment before or after antiretroviral treatment, including failed antiretroviral treatment; local or systemic treatment of lesions to provide largely cosmetic benefit Clinic, Local or district hospital primary prevention, palliation All ages, Adults, Infants or children, Women of childbearing age, Pregnant women, Adolescents and adults, Mothers and infants 52,449 - 34,968-69,930 -- -- 3
HIV/AIDS Treatment of opportunistic infections Personal Opportunistic infection prophylaxis; necessary for patients without access to antiretroviral treatment, for immunosuppressed patients waiting for antiretroviral treatment to take effect, for patients who refuse or cannot take antiretroviral treatment, for Clinic, Local or district hospital primary prevention, cure All ages, Adults, Infants or children, Women of childbearing age, Pregnant women, Adolescents and adults, Mothers and infants 156 - 3-310 -- -- 3
HIV/AIDS Tuberculosis coinfection prevention and treatment Personal Preventive therapy, short-course chemotherapy, or co-trimoxazole prophylaxis Clinic primary prevention, cure All ages, Adults, Infants or children, Women of childbearing age, Pregnant women, Adolescents and adults, Mothers and infants 121 (SubSaharan Africa) - 6-235 (SubSaharan Africa) -- -- 2 (Sub-Saharan Africa)
HIV/AIDS Voluntary counseling and testing Population Routine and voluntary confidential HIV counseling and testing Clinic population-oriented medical intervention Adults, Women of childbearing age, Pregnant women, Adolescents and adults 47 - 10-85 -- -- 2

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