4. Comparative Quantification of Mortality and Burden of Disease Attributable to Selected Risk Factors

Table 4.7: Individual and Joint Contributions of Risk Factors to Mortality and Burden of Disease from Major Diseases of Children

Individual and Joint Contributions of Risk Factors to Mortality and Burden of Disease from Major Diseases of Children
World
DiseaseaDeathsProportion of global disease burden (%) [total: 1.54 billion DALYs(3,0)]PAFs for individual risk factors for mortality (first number) and disease burden (second number)Joint PAF - mortality (%)Joint PAF - disease burden (%)
Measles556,3841.1Childhood underweight (44%; 44%), vitamin A deficiency (20%; 20%)5555
Diarrheal diseases1,598,7543.5Childhood underweight (61%; 55%), vitamin A deficiency (24%; 22%), zinc deficiency (13%; 12%), unsafe water, sanitation, and hygiene (88%; 88%)9493
Lower respiratory infections1,914,1894.0Childhood underweight (54%; 52%), zinc deficiency (21%; 21%), indoor air pollution (49%; 48%)7270
Malaria1,086,2982.3Childhood underweight (55%; 51%), vitamin A deficiency (19%; 19%), zinc deficiency (22%; 22%)6865
Conditions arising during the perinatal period2,520,9865.9Iron-deficiency anemia (16%; 14%)1614
All other childhood diseases2,921,83411.2Partially attributable to childhood underweight and vitamin A deficiency (see annex 4A for details).Not estimatedNot estimated
All causes10,598,44428.0Childhood underweight (27%; 20%), vitamin A deficiency (7%; 5%), zinc deficiency (8%; 6%), unsafe water, sanitation, and hygiene (13%; 11%), indoor air pollution (9%; 7%), iron-deficiency anemia (4%; 3%)4940
Low- and middle-income countries
DiseaseaDeathsProportion of regional disease burden (%) [total: 1.39 billion DALYs(3,0)]PAFs for individual risk factors for mortality (first number) and disease burden (second number)Joint PAF - mortality (%)Joint PAF - disease burden (%)
Measles556,3121.2Childhood underweight (44%; 44%), vitamin A deficiency (20%; 20%)5555
Diarrheal diseases1,598,3363.8Childhood underweight (61%; 56%), vitamin A deficiency (24%; 22%), zinc deficiency (13%; 12%), unsafe water, sanitation, and hygiene (88%; 88%)9493
Lower respiratory infections1,912,5994.4Childhood underweight (54%; 52%), zinc deficiency (21%; 21%), indoor air pollution (49%; 48%)7270
Malaria1,086,2372.6Childhood underweight (55%; 51%), vitamin A deficiency (19%; 19%), zinc deficiency (22%; 22%)6865
Conditions arising during the perinatal period2,488,7186.4Iron-deficiency anemia (16%; 14%)1614
All other childhood diseases2,883,49612.0Partially attributable to childhood underweight and vitamin A deficiency (see annex 4A for details).Not estimatedNot estimated
All causes10,525,69930.5Childhood underweight (27%; 21%), vitamin A deficiency (7%; 5%), zinc deficiency (8%; 7%), unsafe water, sanitation, and hygiene (13%; 11%), indoor air pollution (9%; 7%), iron-deficiency anemia (4%; 3%)4941
High-income countries
DiseaseaDeathsProportion of regional disease burden (%) [total: 149.2 million DALYs(3,0)]PAFs for individual risk factors for mortality (first number) and disease burden (second number)Joint PAF - mortality (%)Joint PAF - disease burden (%)
Measles730.0Childhood underweight (0%; 0%), vitamin A deficiency (1%; 0%)10
Diarrheal diseases4180.2Childhood underweight (0%; 0%), vitamin A deficiency (1%; 0%), zinc deficiency (1%; 1%), unsafe water, sanitation, and hygiene (65%; 65%)6666
Lower respiratory infections1,5900.0Childhood underweight (0%; 0%), zinc deficiency (3%; 3%), indoor air pollution (0%; 0%)11
Malaria610.0Childhood underweight (0%; 0%), vitamin A deficiency (1%; 1%), zinc deficiency (3%; 3%)22
Conditions arising during the perinatal period32,2680.9Iron-deficiency anemia (3%; 2%)32
All other childhood diseases38,3373.4Partially attributable to childhood underweight and vitamin A deficiency (see annex 4A for details).Not estimatedNot estimated
All causes72,7464.6Childhood underweight (0%; 0%), vitamin A deficiency (0%; 0%), zinc deficiency (0%; 0%), unsafe water, sanitation, and hygiene (0%; 2%), indoor air pollution (0%; 0%), iron-deficiency anemia (1%; 0%)24

Source: Authors' calculations.

Note: Risk factors are those listed in table 4.1.

a. By definition, the diseases protein-energy malnutrition (ICD-9 three-digit codes 260-263), iron-deficiency anemia (ICD-9 three-digit codes 280-285), and vitamin A deficiency (ICD-9 three-digit code 264) are 100 percent attributable to their corresponding namesake risk factors. Thus, the PAFs for these diseases are not shown. PAFs, attributable mortality, and attributable disease burden are reported in annex 4A.

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