3. Cost–Effectiveness Analysis

Table 3.1: The Amount of Health US$1 Million Will Buy

The Amount of Health US$1 Million Will Buy
Service or InterventionCost per DALY (US$)DALYs averted per US$1million spent
Reducing Under-Five Mortality
  1. Improved care of children under 28 days old (including resuscitation of newborns)10-4002,500-100,000
  2.1 Expansion of immunization coverage with standard child vaccines2-2050,000-500,000
  2.2 Adding vaccines against additional diseases to the standard child immunization program (particularly against haemophilus influenza and hepatitis B)40-2504,000-24,000
  3. Switching to the use of combination drugs (ACTs) against malaria where there is resistance to current inexpensive and highly effective drugs (Sub-Saharan Africa)8-2050,000-125,000
Preventing and Treating HIV/AIDS
  4. Prevention of mother-to-child transmission (ARV-nevirapine- prophylaxis of the mother; breast-feeding substitutes)50-2005,000-20,000
  5. STI treatment to interrupt HIV transmission10-10010,000-100,000
  6.1 ARV treatment achieving high adherence for a large percentage of patients350-5002,000-3,000
  6.2 ARV treatment that achieves high adherence for a small percentage of patientsbecause of very limited gains by individual patients and the potential for adverse changes in population behavior, there is the possibility that more life years would be lost than saved
Preventing and Treating Noncommunicable Disease
  7. Taxation of tobacco products3-5020,000-330,000
  8.1 Treatment of acute myocardial infarction (AMI) or heart attacks with an inexpensive set of drugs10-2540,000-100,000
  8.2 Treatment of AMI with inexpensive drugs plus streptokinase (costs and DALYs for this are in addition to what would have occurred with inexpensive drugs only)600-7501,300-1,600
  9. Lifelong treatment of heart attack and stroke survivors with a daily "polypill" combining 4 or 5 off-patent preventive medications.700-1,0001,000-1,400
  10.1 CABG or bypass surgery in specific identifiable high risk cases, such as disease of the left main coronary artery (incremental to 9)>25,000<40
  10.2 Bypass surgery for less severe coronary artery disease (incremental to 9)very highvery small
Other
  11. Detection and treatment of cervical cancer15-5020,000-60,000
  12. Operation of a basic surgical ward at the district hospital level focusing on trauma, high risk pregnancy, and other common surgically-treatable conditions70-2504,000-15,000

Sources: DCP2, Chapter 1, table 1.3.

Note: DALYs averted per US$1 million spent on an intervention will vary enormously from country to country and in light of many other factors. This table aims only to provide a very rough sense of how much health can be bought with different interventions and to show that there is huge variation in the amount of different health interventions (or that the same intervention applied in different ways) can provide for the same amount of money.

ACT = artemisinin combination therapy

AMI = acute myocardial infarction

ARV = antiretroviral

CABG = coronary artery bypass graft

STI = sexually transmitted infection